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ankyrin repeat domain-containing protein 11; ankyrin repeat-containing cofactor 1 (ANKRD11, ANCO1)
Function:
- may recruit HDACs to the p160 coactivators - nuclear receptor complex to inhibit ligand-dependent transactivation
- interacts with the PAS region of the p160 coactivators
Structure: contains 4 ANK repeats
Compartment: nucleus
Pathology:
- defects in ANKRD11 are the cause of KBG syndrome
General
ankyrin repeat domain protein (ANKRD)
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 2663 aa
MW = 298 kD
COMPARTMENT: cell nucleus
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 167-196
ankyrin repeat
NAME: ankyrin repeat
SITE: 200-229
ankyrin repeat
NAME: ankyrin repeat
SITE: 233-262
ankyrin repeat
NAME: ankyrin repeat
SITE: 266-292
MOTIF: Ser phosphorylation site {S276}
Ser phosphorylation site {S408}
Thr phosphorylation site {T410}
Ser phosphorylation site {S411}
serine-rich region {478-588}
MOTIF: serine residue (SEVERAL)
lysine-rich region {621-1655}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S834}
Ser phosphorylation site {S843}
Ser phosphorylation site {S846}
Ser phosphorylation site {S848}
Ser phosphorylation site {S849}
Thr phosphorylation site {T1120}
Ser phosphorylation site {S1123}
Thr phosphorylation site {T1419}
Ser phosphorylation site {S1509}
Ser phosphorylation site {S1792}
proline-rich region
SITE: 1824-2365
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S1847}
Ser phosphorylation site {S1852}
Ser phosphorylation site {S1859}
Ser phosphorylation site {S1983}
Ser phosphorylation site {S1990}
Database Correlations
OMIM correlations
UniProt Q6UB99
PFAM correlations
Entrez Gene 29123
Kegg hsa:29123
References
UniProt :accession Q6UB99