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ankyrin repeat domain-containing protein 1 (cardiac ankyrin repeat protein, cytokine-inducible nuclear protein, C-193)
Function:
1) role in endothelial cell activation (putative)
2) nuclear transcription factor that negatively regulates expression of cardiac genes (putative)
3) induction appears correlated with apoptotic cell death in hepatoma cells
4) interacts with YBX1, TTN/titin
Structure: contains 5 ANK repeats
Compartment: nucleus
Expression:
- mainly expressed in activated vascular endothelial cells
- induced by TNF, IL1A & parthenolide
Pathology: expressed in hepatoma cells
General
ankyrin repeat domain protein (ANKRD)
transcription factor (TF)
Properties
SIZE: MW = 36 kD
entity length = 319 aa
COMPARTMENT: cell nucleus
MOTIF: coiled coil {61-89}
ankyrin repeat
NAME: ankyrin repeat
SITE: 152-181
ankyrin repeat
NAME: ankyrin repeat
SITE: 185-214
ankyrin repeat
NAME: ankyrin repeat
SITE: 218-247
ankyrin repeat
NAME: ankyrin repeat
SITE: 251-280
ankyrin repeat
NAME: ankyrin repeat
SITE: 284-315
Database Correlations
UniProt Q15327
Pfam PF00023
References
UniProt :accession Q15327