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ankyrin repeat & SAM domain-containing protein 1A; Odin (ANKS1A, ANKS1, KIAA0229, ODIN)
Function:
- regulates EPHA8 receptor tyrosine kinase signaling to control cell migration & neurite retraction (putative)
- phosphorylated on Tyr in response to EGF & PDGF (putative)
Structure:
- contains 6 ANK repeats
- contains 1 PID domain
- contains 2 SAM (sterile alpha motif) domains
Compartment:
- cytoplasm
- cell projection (putative)
Expression: widely expressed
General
ankyrin repeat domain protein (ANKRD)
sterile alpha motif domain-containing protein (SAMD)
Properties
SIZE: entity length = 1134 aa
MW = 123 kD
COMPARTMENT: cytoplasm
MOTIF: glycine-rich region {2-55}
ankyrin repeat
NAME: ankyrin repeat
SITE: 79-108
ankyrin repeat
NAME: ankyrin repeat
SITE: 112-141
ankyrin repeat
NAME: ankyrin repeat
SITE: 148-177
ankyrin repeat
NAME: ankyrin repeat
SITE: 181-210
ankyrin repeat
NAME: ankyrin repeat
SITE: 214-243
ankyrin repeat
NAME: ankyrin repeat
SITE: 246-275
Thr phosphorylation site {T318}
Tyr phosphorylation site {Y455}
Ser phosphorylation site {S622}
Ser phosphorylation site {S624}
Ser phosphorylation site {S626}
Ser phosphorylation site {S628}
Ser phosphorylation site {S647}
Ser phosphorylation site {S661}
Ser phosphorylation site {S663}
Ser phosphorylation site {S666}
Ser phosphorylation site {S677}
sterile alpha motif
NAME: sterile alpha motif
SITE: 696-762
sterile alpha motif
NAME: sterile alpha motif
SITE: 770-837
Ser phosphorylation site {S887}
phosphotyrosine interaction domain
NAME: phosphotyrosine interaction domain
SITE: 936-1091
Database Correlations
OMIM 608994
UniProt Q92625
PFAM correlations
Entrez Gene 23294
Kegg hsa:23294
References
UniProt :accession Q92625