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ankyrin repeat & BTB/POZ domain-containing protein 1 (elongation factor 1A-binding protein, ABTB1, BPOZ, PP2259)
Function:
1) mediator of the PTEN growth-suppressive signaling (putative)
2) role in developmental processes (putative)
Structure:
- contains 2 ANK repeats contains 2 BTB domains (POZ domains)
Compartment: cytoplasm
Alternative splicing: named isoforms=4
Expression:
- ubiquitously expressed in fetal tissues, including heart, brain, liver, kidney
- expressed at lower levels in adult heary
General
ankyrin repeat domain protein (ANKRD)
BTB/POZ domain containing protein
Properties
SIZE: MW = 54 kD
entity length = 478 aa
COMPARTMENT: cytoplasm
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 1-31
ankyrin repeat
NAME: ankyrin repeat
SITE: 35-64
BTB domain {115-182}
MOTIF: Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
BTB domain {272-346}
MOTIF: Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
coiled coil {451-477}
Database Correlations
OMIM 608308
UniProt Q969K4
PFAM correlations
References
UniProt :accession Q969K4