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Notch/ankyrin repeat
Tandemly repeated module of about 33 amino acid residues origionally identified as a site anchoring ankyrin to tubulin. It is present in transmembrane receptors, cytoskeletal proteins & transcription factors. It mediates protein-protein interactions crucial for intercellular signalling (4).
Related
ankyrin
ankyrin repeat domain protein (ANKRD)
General
binding site
peptide motif
consensus repeat
Properties
NAME: ankyrin repeat
MISC-INFO: LENGTH 33 AMINO-ACID-RES
References
- Thompson CC, Brown TA, McKnight SL.
Convergence of Ets- and notch-related structural motifs in
a heteromeric DNA binding complex.
Science. 1991 Aug 16;253(5021):762-8.
PMID: 1876833
- LaMarco K, Thompson CC, Byers BP, Walton EM, McKnight SL.
Identification of Ets- and notch-related subunits in GA
binding protein.
Science. 1991 Aug 16;253(5021):789-92.
PMID: 1876836
- Hoffman M.
New role found for a common protein "motif".
Science. 1991 Aug 16;253(5021):742.
PMID: 1831563
- Pawson T
Protein modules and signalling networks
Nature 373:573 1995 (Notch)
PMID: 7531822