ankycorbin (ankyrin repeat & coiled-coil structure-containing protein, retinoic acid-induced protein 14, novel retinal pigment epithelial cell protein, RAI14, KIAA1334, NORPEG)

Compartment: - cytoplasm, cell cortex, cytoskeleton - associated with cortical actin cytoskeleton in terminal web & cell-cell adhesion sites & stress fibers - doesn't bind directly to F-actin Structure: - contains 7 ANK repeats Alternative splicing: named isoforms=3 Expression: - expressed in placenta, muscle, kidney, testis > heart, brain, lung, liver , intestine - isoform 2 is widely expressed & expressed in fetal & adult testes, & spermatozoa - up-regulated by all-trans-retinoic acid in human retinal pigment epithelial cells

General

cytoskeletal protein retinoic acid-induced protein (RAI)

Properties

SIZE: MW = 110 kD entity length = 980 aa COMPARTMENT: cytoplasm MOTIF: ankyrin repeat NAME: ankyrin repeat SITE: 18-51 ankyrin repeat NAME: ankyrin repeat SITE: 52-81 ankyrin repeat NAME: ankyrin repeat SITE: 85-114 ankyrin repeat NAME: ankyrin repeat SITE: 118-147 ankyrin repeat NAME: ankyrin repeat SITE: 151-180 ankyrin repeat NAME: ankyrin repeat SITE: 184-213 ankyrin repeat NAME: ankyrin repeat SITE: 217-247 coiled coil {349-374} coiled coil {425-947}

Database Correlations

OMIM 606586 UniProt Q9P0K7 Pfam PF00023

References

UniProt :accession Q9P0K7