anion exchange protein 3 (neuronal band 3-like protein, cardiac/brain band 3-like protein, CAE3/BAE3, solute carrier family 4 member 3, SLC4A3, SLC2, AE3)

Function: - plasma membrane anion exchange protein of wide distribution - mediates at least a part of the Cl-/HCO₃^- exchange in cardiac myocytes - both isoforms BAE3 & CAE3 transport Cl- Structure: belongs to the anion exchanger (TC 2.A.31) family Compartment: membrane Alternative splicing: named isoforms=2, BAE3, CAE3 Additional isoforms seem to exist Expression: - both BAE3 & CAE3 isoforms are expressed in failing ventricle Laboratory: - anion exchange protein 3 Ag in tissue

General

anion exchange protein Cl- channel glycoprotein plasma membrane protein solute carrier family 4 (SLC4, SLC4A)

Properties

SIZE: MW = 136 kD entity length = 1232 aa COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-708} MOTIF: glutamate residue {136-149} (14) proline-rich region SITE: 152-161 MOTIF: proline residue (SEVERAL) serine residue {202-207} (6) lysine residue {308-313} (6) serine residue {442-445} (4) transmembrane domain {709-731} exoplasmic loop {732-736} transmembrane domain {737-774} cytoplasmic loop {775-793} transmembrane domain {794-816} exoplasmic loop {817-825} transmembrane domain {826-847} cytoplasmic loop {848-892} transmembrane domain {893-910} exoplasmic loop {911-925} transmembrane domain {926-946} cytoplasmic loop {947-979} transmembrane domain {980-1002} exoplasmic loop {1003-1027} transmembrane domain {1028-1049} cytoplasmic loop {1050-1082} transmembrane domain {1083-1128} exoplasmic loop {1129-1154} transmembrane domain {1155-1191} MOTIF: cysteine residue {C1165} MODIFICATION: palmitate COMPARTMENT: membrane leucine residue {1184-1187} (4) cytoplasmic domain {1188-1232} ION-PERMEABILITY: Cl-

Database Correlations

OMIM 106195 UniProt P48751 PFAM correlations