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angiotensin II type 2 & 4 stimulating agent
Pathology:
- initiation of antihypertensive medications that stimulate vs inhibit type 2 & 4 angiotensin II receptors may result in a lower risk of dementia [1]
Pharmacology:
- angiotensin II receptor inhibitors
- azilsartan
- candesartan
- eprosartan
- irbesartan
- losartan
- olmesartan
- telmisartan
- valsartan
- calcium channel blockers (dihydropyridine)
- amlodipine
- felodipine
- isradipine
- nicardipine
- nifedipine
- nimodipine
- nisoldipine
- thiazide diuretics
- chlorothiazide
- chlorthalidone
- hydrochlorothiazide
- hydroflumethiazide
- indapamide
- methylclothiazide
- polythiazide
- trichlormethiazide
Interactions
drug adverse effects of antihypertensive agents
General
antihypertensive agent
References
- Anderson P
Some BP Meds Tied to Significantly Lower Risk for Dementia, Alzheimer's.
Medscape. Jan 20, 2023
https://www.medscape.com/viewarticle/986775
- Marcum ZA, Gabriel N, Bress AP et al
Association of New Use of Antihypertensives That Stimulate vs Inhibit Type 2
and 4 Angiotensin II Receptors With Dementia Among Medicare Beneficiaries.
JAMA Netw Open. 2023;6(1):e2249370.
PMID: 36598787
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800004