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angiotensin II type 2 & 4 inhibiting agent

Pathology: - initiation of antihypertensive medications that stimulate vs inhibit type 2 & 4 angiotensin II receptors may result in a lower risk of dementia [1] Pharmacology: - ACE inhibitors - benazepril - captopril - enalapril - fosinopril - lisinopril - moexipril - perindopril - quinapril - ramipril - trandolapril - beta-blockers - acebutolol - atenolol - betaxolol - bisoprolol - carteolol - carvedilol - metoprolol - nadolol - nebivolol - penbutolol - pindolol - propranolol - sotalol - timolol - calcium channel blockers (non-dihydropyridine) - diltiazem - verapamil

Interactions

drug adverse effects of antihypertensive agents

General

antihypertensive agent

References

  1. Anderson P Some BP Meds Tied to Significantly Lower Risk for Dementia, Alzheimer's. Medscape. Jan 20, 2023 https://www.medscape.com/viewarticle/986775 - Marcum ZA, Gabriel N, Bress AP et al Association of New Use of Antihypertensives That Stimulate vs Inhibit Type 2 and 4 Angiotensin II Receptors With Dementia Among Medicare Beneficiaries. JAMA Netw Open. 2023;6(1):e2249370. PMID: 36598787 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800004