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angiotensin II receptor type 2 & 4-stimulating antihypertensive
Classification:
- angiotensin II receptor antagonist
- dihydropyridine calcium channel blockers
- thiazide diuretic
Clinical significance:
- lower risk of Alzheimer dementia & vascular dementia than with angiotensin II receptor type 2 & 4-inhibiting antihypertensive (RR= ~0.8)[1]
Interactions
drug adverse effects of renin-angiotensin-aldosterone system inhibitors (RAAS inhibitors)
Specific
angiotensin II receptor antagonist (ARB)
dihydropyridine Ca+2 channel blocker (CCB)
thiazide diuretic
General
renin-angiotensin-aldosterone system inhibitor (RAAS inhibitor)
References
- Marcum ZA, Cohen JB, Zhang Cet al
Association of Antihypertensives That Stimulate vs Inhibit Types 2 and 4
Angiotensin II Receptors With Cognitive Impairment.
JAMA Netw Open. 2022;5(1):e2145319. Jan 28
PMID: 35089354 Free article
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788465