Search
angiotensin-converting enzyme 1
Function:
- converts angiotensin 1 to angiotensin 2. [angiotensin 2 is the biologically active form]
Compartment:
- present in plasma & on surface of endothelial cells
- ACE presumptively anchors to the exoplasmic face of endothelial cells via glycosylphosphatidyl inositol
Related
angiotensin I
angiotensin II (Giapreza)
angiotensin-converting enzyme (ACE) in serum/plasma/blood
Specific
angiotensin-converting enzyme 1
angiotensin-converting enzyme 1
General
angiotensin converting enzyme (ACE)
Properties
COMPARTMENT: blood
plasma membrane
CELL-REGION: apical region
CELL: endothelial cell
MOTIF: active site
MOTIF: Zn+2-binding site
EFFECTOR-BOUND: Zn+2
MOTIF: histidine residue (2)
glutamate residue
glycosyl phosphatidylinositol [GPI] membrane anchor {C-TERMINUS}
SECRETED-BY: endothelial cell
Database Correlations
OMIM 106180
Entrez Gene 1636
ENZYME 3.4.15.1
References
- OMIM :accession 106170
- Clinical Diagnosis & Management by Laboratory Methods,
J.B. Henry (ed), W.B. Saunders Co., Philadelphia,
PA. 1991, pg 274
- PROSITE :accession PS00142
- Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed)
Lippincott-Raven, Philadelphia, 1998, pg 753