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angiostatin
Function:
- angiogenesis inhibitor
- interacts with CSPG4 & AMOT
Expression:
- activity copurifies with a 38 kD plasminogen fragment which includes first four kringle domains
- derived fromm plaminogen
Related
plasminogen; contains: plasmin heavy chain A; activation peptide; angiostatin; plasmin light chain B (PLG)
General
endogenous angiogenesis inhibitor
secreted protein
Properties
COMPARTMENT: extracellular compartment
SIZE: MW = 38 kD
References
- O'Reilly MS et al
Angiostatin: a novel angiogenesis inhibitor that mediates the
suppression of metastases by a Lewis lung carcinoma.
Cell. 1994 Oct 21;79(2):315-28.
PMID: 7525077
- UniProt :accession P00747