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angiopoietin-related protein 3; angiopoietin-like protein 3; angiopoietin-5; ANG-5 (ANGPTL3, ANGPT5, UNQ153/PRO179)
Function:
- ANGPTL3 inhibits lipoprotein lipase & endothelial lipase [3]
Structure:
- contains 1 fibrinogen C-terminal domain
Compartment: secreted (putative)
Expression:
- expressed predominantly in liver
- weakly expressed in kidney
Pharmacology:
- evinacumab-dgnb (Evkeeza) is a recombinant monoclonal Ab that binds to & inhibits angiopoietin-like 3 (ANGPTL3) FDA-approved for treatment of homozygous familial hypercholesterolemia
General
angiopoietin
angiopoietin like
glycoprotein
secreted protein
Properties
SIZE: entity length = 460 aa
MW = 54 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-16}
coiled coil {85-210}
MOTIF: N-glycosylation site {N115}
Fibrinogen C-terminal {237-455}
MOTIF: cysteine residue {C246}
MODIFICATION: cysteine residue {C274}
cysteine residue {C274}
MODIFICATION: cysteine residue {C246}
N-glycosylation site {N296}
N-glycosylation site {N357}
cysteine residue {C394}
MODIFICATION: cysteine residue {C408}
cysteine residue {C408}
MODIFICATION: cysteine residue {C394}
Database Correlations
OMIM 604774
UniProt Q9Y5C1
Pfam PF00147
Entrez Gene 27329
Kegg hsa:27329
References
- Entrez Gene :accession 27329
- UniProt :accession Q9Y5C1
- Styles S
FDA Approves Orphan Drug Evinacumab-dgnb for Homozygous FH
Medscape - Feb 11, 2021.
https://www.medscape.com/viewarticle/945719