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angiopoietin-related protein 2; angiopoietin-like protein 2 (ANGPTL2 ARP2 UNQ170/PRO196)
Function:
- induces sprouting in endothelial cells through an autocrine & paracrine action
Structure:
- N-glycosylated
- contains 1 fibrinogen C-terminal domain
Compartment: secreted
Expression:
- widely expressed in heart, small intestine, spleen & stomach
- also found in lower levels in colon, ovary, adrenal gland, skeletal muscle & in prostate
Related
angiopoietin
General
angiopoietin like
secreted protein
Properties
SIZE: entity length = 493 aa
MW = 57 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
coiled coil {76-115}
coiled coil {152-206}
MOTIF: N-glycosylation site {N164}
N-glycosylation site {N192}
Fibrinogen C-terminal {269-489}
MOTIF: cysteine residue {C278}
MODIFICATION: cysteine residue {C307}
cysteine residue {C307}
MODIFICATION: cysteine residue {C278}
cysteine residue {C430}
MODIFICATION: cysteine residue {C443}
cysteine residue {C443}
MODIFICATION: cysteine residue {C430}
Database Correlations
OMIM 605001
UniProt Q9UKU9
Pfam PF00147
Entrez Gene 23452
Kegg hsa:23452
References
- UniProt :accession Q9UKU9
- Entrez Gene :accession 23452