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angiopoietin-4; ANG-4; angiopoietin-3; ANG-3 (ANGPT4, ANG3, ANG4)
Function:
- binds to tyrosine-protein kinase receptor TIE2 & activates it
Structure: contains 1 fibrinogen C-terminal domain
Compartment: secreted (probable)
Expression:
- highly expressed in the lung
- much lower levels found in other tissues
General
angiopoietin
secreted protein
Properties
SIZE: entity length = 503 aa
MW = 57 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-24}
coiled coil {84-238}
MOTIF: N-glycosylation site {N96}
N-glycosylation site {N126}
N-glycosylation site {N140}
N-glycosylation site {N158}
N-glycosylation site {N247}
N-glycosylation site {N274}
Fibrinogen C-terminal {282-502}
MOTIF: cysteine residue {C291}
MODIFICATION: cysteine residue {C320}
N-glycosylation site {N311}
cysteine residue {C320}
MODIFICATION: cysteine residue {C291}
N-glycosylation site {N337}
N-glycosylation site {N427}
cysteine residue {C444}
MODIFICATION: cysteine residue {C457}
cysteine residue {C457}
MODIFICATION: cysteine residue {C444}
Database Correlations
OMIM 603705
UniProt Q9Y264
Pfam PF00147
Entrez Gene 51378
Kegg hsa:51378
References
- UniProt :accession Q9Y264
- Entrez Gene :accession 51378