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angiopoietin-2; ANG-2 (ANGPT2)
Function:
- can induce Tyr phosphorylation of TIE2
- binds to TIE2 receptor & counteracts blood vessel maturation & stability mediated by angiopoietin-1
- its function may be context-dependent
- in the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression
- in concert with VEGF, it may facilitate endothelial cell migration & proliferation, thus serving as a permissive angiogenic signal
Structure:
- contains 1 fibrinogen C-terminal domain
Compartment: secreted
Alternative splicing: named isoforms=2
General
angiopoietin
secreted protein
Properties
SIZE: entity length = 496 aa
MW = 57 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-18}
N-glycosylation site {N89}
N-glycosylation site {N119}
N-glycosylation site {N133}
N-glycosylation site {N151}
coiled coil {166-248}
MOTIF: N-glycosylation site {N240}
Fibrinogen C-terminal {275-495}
MOTIF: cysteine residue {C284}
MODIFICATION: cysteine residue {C313}
N-glycosylation site {N304}
cysteine residue {C313}
MODIFICATION: cysteine residue {C284}
cysteine residue {C437}
MODIFICATION: cysteine residue {C450}
cysteine residue {C450}
MODIFICATION: cysteine residue {C437}
Database Correlations
OMIM 601922
UniProt O15123
Pfam PF00147
Entrez Gene 285
Kegg hsa:285
References
- UniProt :accession O15123
- Entrez Gene :accession 285
- Wikipedia; Note: angiopoietin entry
http://en.wikipedia.org/wiki/angiopoietin