Search
angiopoietin-1; ANG-1 (ANGPT1 KIAA0003)
Function:
- binds & activates TIE2 receptor by inducing its Tyr phosphorylation
- implicated in endothelial developmental processes later & distinct from that of VEGF
- role in mediating reciprocal interactions between the endothelium & surrounding matrix & mesenchyme
- mediates blood vessel maturation & stability
- may play a role in early heart development
Structure:
- glycosylated
- contains 1 fibrinogen C-terminal domain
Compartment: secreted
Pharmacology:
- may have a therapeutic utility
a) specifically targeting tumor vasculature
b) promoting angiogenic processes in ischemic heart
General
angiopoietin
secreted protein
Properties
SIZE: entity length = 498 aa
MW = 58 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-15}
coiled coil {81-119}
MOTIF: N-glycosylation site {N92}
N-glycosylation site {N122}
coiled coil {153-261}
MOTIF: N-glycosylation site {N154}
N-glycosylation site {N243}
Fibrinogen C-terminal {277-497}
MOTIF: cysteine residue {C286}
MODIFICATION: cysteine residue {C315}
N-glycosylation site {N295}
cysteine residue {C315}
MODIFICATION: cysteine residue {C286}
cysteine residue {C439}
MODIFICATION: cysteine residue {C452}
cysteine residue {C452}
MODIFICATION: cysteine residue {C439}
Database Correlations
OMIM 601667
UniProt Q15389
Pfam PF00147
Entrez Gene 284
Kegg hsa:284
References
- Entrez Gene :accession 284
- UniProt :accession Q15389
- Wikipedia; Note: angiopoietin entry
http://en.wikipedia.org/wiki/angiopoietin