angioimmunoblastic T-cell lymphoma (AILD)

Classification: 1) working formulation: - diffuse, mixed small & large cell lymphoma - large cell immunoblastic lymphoma. 2) Kiel classification: angioimmunoblastic (AILD) Pathology: 1) obliteration of lymph node architecture 2) proliferation of mature lymphocytes, plasma cells & immunoblasts 3) PAS +/eosinophilic sludgy material 4) vascular proliferation, small vessels, with endothelial proliferation 5) immunophenotype: - T-cell associated antigens, usually CD4+ Genetics: - TCR genes rearranged in ~75%, IgH in~10% Clinical manifestations: 1) lymphadenopathy 2) extranodal disease 3) skin manifestations

General

diffuse mixed small & large cell lymphoma peripheral T-cell lymphoid neoplasm

References

Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998