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atrial natriuretic peptide receptor A; atrial natriuretic peptide A-type receptor; ANPRA; ANP-A; NPR-A; guanylate cyclase; GC-A (NPR1, ANPRA)
Function:
- receptor for atrial natriuretic peptide
- has guanylate cyclase activity on binding of ANF
- phosphorylation of the protein kinase-like domain is required for full activation by ANP (putative)
Structure:
- belongs to the adenylyl cyclase class-4/guanylyl cyclase family
- contains 1 guanylate cyclase domain
- contains 1 protein kinase domain
Compartment: membrane
Pathology:
- polymorphism in ANF receptor type A gene associated with left ventricular hypertrophy & decreased serum atrial natriuretic factor [2]
General
glycoprotein
guanyl cyclase or guanylate cyclase
natriuretic peptide receptor
phosphoprotein
Properties
SIZE: entity length = 1061 aa
MW = 119 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-32}
N-glycosylation site {N34}
N-glycosylation site {N45}
binding site
SITE: 85-85
FOR-BINDING-OF: Chloride
cysteine residue {C92}
MODIFICATION: cysteine residue {C118}
binding site
SITE: 117-117
FOR-BINDING-OF: Chloride; via amide nitrogen
binding site
SITE: 118-118
FOR-BINDING-OF: Chloride; via amide nitrogen
MOTIF: cysteine residue {C118}
MODIFICATION: cysteine residue {C92}
cysteine residue {C196}
MODIFICATION: cysteine residue {C245}
N-glycosylation site {N212}
cysteine residue {C245}
MODIFICATION: cysteine residue {C196}
N-glycosylation site {N338}
N-glycosylation site {N379}
N-glycosylation site {N386}
N-glycosylation site {N427}
cysteine residue {C455}
MODIFICATION: cysteine residue {C464}
cysteine residue {C464}
MODIFICATION: cysteine residue {C455}
transmembrane domain {474-494}
kinase domain
SITE: 528-805
MOTIF: ATP-binding site
NAME: ATP-binding site
Ser phosphorylation site {S529}
Thr phosphorylation site {T532}
Ser phosphorylation site {S534}
Ser phosphorylation site {S538}
Ser phosphorylation site {S542}
Thr phosphorylation site {T545}
Guanylate cyclase {876-1006}
Database Correlations
OMIM 108960
UniProt P16066
PFAM correlations
Kegg hsa:4881
References
- UniProt :accession P16066
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 716
- Rabattu S et al,
Association of atrial natriuretic peptide and type A
natriuretic peptide receptor gene polymorphisms with left
ventricular mass in human essential hypertension.
J Am Coll Cardiol 2006, 48:499
PMID: 16875975
- London B,
Natriuretic peptides and cardiac hypertrophy
J Am Coll Cardiol 2006, 48:506
PMID: 16875976