androgen-induced proliferation inhibitor (androgen-induced prostate proliferative shutoff-associated protein AS3, sister chromatid cohesion protein PDS5 homolog B, APRIN, AS3, KIAA0979, PDS5B)

Function: - role in androgen-induced proliferative arrest in prostate cells - required for maintenance of sister chromatid cohesion during mitosis - interacts with the cohesin complex - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - contains 3 A.T hook DNA-binding domains - contains 1 HEAT repeat Compartment: nucleus Alternative splicing: named isoforms=5 Expression: - widely expressed - induced by the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest - maximum levels occur 18-20 hours after androgen exposure Pathology: - defects in APRIN may be the cause of some cancers, including esophageal cancer

General

nuclear protein phosphoprotein

Properties

SIZE: MW = 165 kD entity length = 1447 aa COMPARTMENT: cell nucleus MOTIF: HEAT repeat {383-419} Ser phosphorylation site {S1166} A+T hook SITE: 1249-1261 MOTIF: Ser phosphorylation site {S1257} Ser phosphorylation site {S1259} A+T hook SITE: 1287-1299 Ser phosphorylation site {S1358} Thr phosphorylation site {T1367} Thr phosphorylation site {T1370} A+T hook SITE: 1372-1384 MOTIF: Ser phosphorylation site {S1383}

Database Correlations

OMIM 605333 UniProt Q9NTI5 PFAM correlations

References

UniProt :accession Q9NTI5