ancrod

Snake venom protease. Derived from the venom of the Malaysian pit viper. Pharmacology: Contraindications: - of no benefit in acute stroke Adverse effects: - hemorrhage, including intracranial hemorrhage Mechanism of action: 1) cleavage of fibronectin

General

reptilian-specific molecule serine protease trypsin family toxin (hazardous material, poison)

Properties

MOTIF: charge relay system MOTIF: aspartate residue histidine residue serine residue

References

- Hennerici MG et al, Intravenous ancrod for ischaemic stroke in the European Stroke Treatment with Ancrod Trial: A randomized controlled trial. Lancet 2006, 368:1871 PMID: 17126719