anaphase promoting complex subunit 1 (APC1, cyclosome subunit 1, protein Tsg24, testis-specific gene 24 protein, mitotic checkpoint regulator, ANAPC1, TSG24)

Function: - component of the anaphase promoting complex/cyclosome (APC/C) - phosphorylation on Ser-355 occurs specifically during mitosis Structure: - belongs to the APC1 family - contains 4 PC repeats

General

glycoprotein membrane protein nuclear protein phosphoprotein protein subunit secreted protein zinc finger protein

Properties

SIZE: entity length = 1944 aa MW = 216 kD MOTIF: Ser phosphorylation site {S202} Ser phosphorylation site {S286} Thr phosphorylation site {T291} Ser phosphorylation site {S355} Ser phosphorylation site {S373} Ser phosphorylation site {S377} Thr phosphorylation site {T537} Tyr phosphorylation site {Y571} Ser phosphorylation site {S686} Ser phosphorylation site {S688} Ser phosphorylation site {S731} proteasome/cyclosome repeat {1297-1325} proteasome/cyclosome repeat {1366-1404} proteasome/cyclosome repeat {1467-1501} proteasome/cyclosome repeat {1520-1552}

Database Correlations

OMIM 608473 UniProt Q9H1A4 Pfam PF01851 Kegg hsa:6468

References

UniProt :accession Q9H1A4