partitioning defective 3 homolog B; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein; PAR3-beta; partitioning defective 3-like protein; PAR3-L protein (PARD3B, ALS2CR19, PAR3B, PAR3L)

Function: - putative adapter protein involved in asymmetrical cell division & cell polarization processes - may play a role in formation of epithelial tight junctions - interacts with PARD6B. interacts with INSC/inscuteable Structure: - the N-terminal part (1-351) part blocks the association of the tight junction marker TJP1 with the cell-cell boundary when it is overexpressed - belongs to the PAR3 family - contains 3 PDZ domain (DHR domain)s Compartment: - endomembrane system - cell junction, tight junction - partially localized along the cell-cell contact region - colocalizes with TJP1 to epithelial tight junctions Alternative splicing: named isoforms=5 Expression: - highly expressed in kidney, lung & skeletal muscle - expressed at intermediate levels in brain, heart, placenta, liver & pancreas - isoform 1 is predominant isoform

General

cytoskeletal protein phosphoprotein

Properties

SIZE: entity length = 1205 aa MW = 132 kD COMPARTMENT: cytoplasm MOTIF: PDZ domain NAME: PDZ domain SITE: 201-289 Ser phosphorylation site {S368} PDZ domain NAME: PDZ domain SITE: 383-468 PDZ domain NAME: PDZ domain SITE: 498-585 Ser phosphorylation site {S730} Ser phosphorylation site {S746} Ser phosphorylation site {S749} lysine-rich region {830-896} MOTIF: lysine residue (SEVERAL) Ser phosphorylation site {S990} Tyr phosphorylation site {Y1000} proline-rich region SITE: 1144-1149 MOTIF: proline residue (SEVERAL)

Database Correlations

UniProt Q8TEW8 PFAM correlations Entrez Gene 117583 Kegg hsa:117583

References

UniProt :accession Q8TEW8