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amphiregulin; AR; colorectum cell-derived growth factor; CRDGF (AREG, SDGF,, AREGB)
Function:
- binds to EGF-receptor with lower affinity than EGF
- autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells & fibroblasts
- the immature precursor interacts with CNIH
Structure:
- belongs to the amphiregulin family
- contains 1 EGF-like domain
- contains Cys in disulfide linkage(s) that are essential for biological activity
- may contain oligosaccharides &/or lipid moieties that are not obligatory for biological activity
Compartment: membrane
Expression:
- induced by phorbol 12-myristate 13-acetate (PMA)
General
glycoprotein
membrane protein
secreted protein
Properties
SIZE: entity length = 252 aa
MW = 28 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-19}
N-glycosylation site {N30}
N-glycosylation site {N113}
N-glycosylation site {N119}
EGF domain {142-182}
MOTIF: cysteine residue {C146}
MODIFICATION: cysteine residue {C159}
cysteine residue {C154}
MODIFICATION: cysteine residue {C170}
cysteine residue {C159}
MODIFICATION: cysteine residue {C146}
cysteine residue {C170}
MODIFICATION: cysteine residue {C154}
cysteine residue {C172}
MODIFICATION: cysteine residue {C181}
cysteine residue {C181}
MODIFICATION: cysteine residue {C172}
transmembrane domain {199-221}
Database Correlations
OMIM 104640
UniProt P15514
LOCUS-LINK correlations
KEGG correlations
References
- UniProt :accession P15514
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/AREGID690ch4q13.html
- NIEHS-SNPs
http://egp.gs.washington.edu/data/areg/
- OMIM :accession 104640
- Entrez Gene :accession 374