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amoxicillin/vonoprazan
Indications:
- treatment of Helicobacter pylori infection (FDA approved May 2022)
Adverse effects:
- dysgeusia, diarrhea, abdominal pain, headache, nasopharyngitis, hypertension, vulvovaginal candidiasis
- Stevens-Johnson syndrome & toxic epidermal necrolysis
- C difficile-associated diarrhea
Notes:
- available Fall 2022
General
pharmacologic combination
References
- Hamza Z
Two New Regimens Win FDA Approval for H. Pylori Infection.
Dual and triple vonoprazan-based treatments offer physicians another set of options.
MedPage Today May 4, 2022
https://www.medpagetoday.com/gastroenterology/generalgastroenterology/98547
- Rokkas T, Ekmektzoglou K, Niv Y, et al.
Comparative Efficacy and Safety of Potassium-Competitive Acid Blocker-Based Dual,
Triple, and Quadruple Regimens for First-Line Helicobacter pylori Infection Treatment:
A Systematic Review and Network Meta-Analysis.
Am J Gastroenterol. 2024 Sep 19
PMID: 39298553
https://journals.lww.com/ajg/abstract/9900/comparative_efficacy_and_safety_of.1334.aspx
Components
amoxicillin (Amoxil, Polymox, Larotid, Trimox, DisperMox, Moxatag, A-cillin)
vonoprazan (Voquezna)