ammonium transporter Rh type B (Rh family type B glycoprotein, Rhesus blood group family type B glycoprotein, Rh type B glycoprotein, RHBG)

Function: - specific ammonium transporter - interacts with ANK2 & ANK3, required for targeting to basolateral membrane Structure: - belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily - N-glycosylated Compartment: - basolateral cell membrane - cytoplasmic vesicle Alternative splicing: named isoforms=3 Expression: - specifically expressed in kidney - detected in liver & ovary - expressed in fetal kidney > liver

General

carrier protein (transporter) glycoprotein transmembrane 12 protein

Properties

SIZE: MW = 49 kD entity length = 458 aa COMPARTMENT: cytoplasm MOTIF: cytoplasmic domain {1-13} transmembrane domain {14-34} exoplasmic loop {35-61} MOTIF: N-glycosylation site {N49} transmembrane domain {62-82} cytoplasmic loop {83-86} transmembrane domain {87-107} exoplasmic loop {108-124} transmembrane domain {125-145} cytoplasmic loop {146-149} transmembrane domain {150-170} exoplasmic loop {171-178} transmembrane domain {179-201} cytoplasmic loop {202-219} transmembrane domain {220-240} exoplasmic loop {241-251} transmembrane domain {252-272} cytoplasmic loop {273-282} transmembrane domain {283-303} exoplasmic loop {304-304} transmembrane domain {305-325} cytoplasmic loop {326-346} transmembrane domain {347-367} exoplasmic loop {368-393} transmembrane domain {394-414} cytoplasmic domain {415-458} MOTIF: sorting signal {429-432}

Database Correlations

OMIM 607079 UniProt Q9H310 Pfam PF00909

References

UniProt :accession Q9H310