amino acid transport protein

Na⁺ is co-transported with a subset of amino acids. The Na⁺ gradient provides the driving force for the transport. 5 separate amino acid transport proteins have been identified.

Specific

amino acid transporter-1; ATR1; solute carrier family 3 member 1; SLC3A1; neutral & basic amino acid transport protein rBAT; B(0,+)-type amino acid transport protein; NBAT; D2H; cystine-dibasic & neutral amino acid transporter aspartate/glutamate translocase or aspartate/glutamate carrier protein cationic amino acid transporter-4 (CAT4, solute carrier family 7 member 4, SLC7A4) glutamate/aspartate transporter (excitatory amino acid transporter) high affinity cationic amino acid transporter 1; CAT-1; CAT1; system Y+ basic amino acid transporter; solute carrier family 7 member 1; ecotropic retroviral leukemia receptor homolog; ecotropic retrovirus receptor homolog; ERR (SLC7A1, ATRC1, ERR, REC1L) L-type amino acid transporter 1-like protein IMAA; hLAT1-3-transmembrane protein IMAA; hLAT1-3TM IMAA; solute carrier family 7 member 5P2 (IMAA, SLC7A5P2) large neutral amino acids transporter small subunit 4 (L-type amino L-acid transporter 4, solute carrier family 43 member 2, SLC43A2, LAT4, PP7664) low affinity cationic amino acid transporter 2; CAT-2; CAT2; solute carrier family 7 member 2 (SLC7A2, ATRC2) Na+-coupled neutral amino acid transporter 10; solute carrier family 38 member 10 (SLC38A10) Na+-coupled neutral amino acid transporter 4 (amino acid transporter A3, system A amino acid transporter 3, system N amino acid transporter 3, solute carrier family 38 member 4, SLC38A4, ATA3, NAT3, SNAT4) Na+-coupled neutral amino acid transporter 6 (Na+-coupled neutral amino acid transporter 6, N-system amino acid transporter 1, NAT-1, solute carrier family 38 member 6, SLC38A6, NAT1, SNAT6) Na+-coupled neutral amino acid transporter 7; solute carrier family 38 member 7 (SLC38A7) Na+-coupled neutral amino acid transporter 8; solute carrier family 38 member 8 (SLC38A8) Na+/Cl- dependent glycine transporter 1; GlyT1; solute carrier family 6 member 9 (SLC6A9) Na+/neutral amino acid cotransporter or neutral amino acid transporter neutral amino acid transporter A; alanine/serine/cysteine/threonine transporter; ASCT1; SATT; solute carrier family 1 member 4 (SLC1A4, ASCT1, SATT)

General

glycoprotein symporter

Properties

COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {N-TERMINAL} transmembrane domain {TM1} exoplasmic loop LOOP#: 1 transmembrane domain {TM2} cytoplasmic loop LOOP#: 1 transmembrane domain {TM3} exoplasmic loop MOTIF: N-glycosylation site cysteine residue {L2.1} MODIFICATION: cysteine residue {L2.2} cysteine residue {L2.2} MODIFICATION: cysteine residue {L2.1} LOOP#: 2 transmembrane domain {TM4} cytoplasmic loop LOOP#: 2 transmembrane domain {TM5} exoplasmic loop LOOP#: 3 transmembrane domain {TM6} cytoplasmic loop LOOP#: 3 transmembrane domain {TM7} exoplasmic loop LOOP#: 4 transmembrane domain {TM8} cytoplasmic loop LOOP#: 4 transmembrane domain {TM9} exoplasmic loop LOOP#: 5 transmembrane domain {TM10} cytoplasmic loop LOOP#: 5 transmembrane domain {TM11} exoplasmic loop LOOP#: 6 transmembrane domain {TM12} cytoplasmic domain {C-TERMINAL}

References

Textbook of Medical Physiology, 8th ed., AC Guyton, WB Saunders, Philadelphia, 1991, pg 49