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aminophylline (ethylene diamine/theophylline, Somophyllin-DF)

A 1:1 complex of ethylenediamine & theophylline. Tradenames: Somophyllin, Somophyllin-DF. Contraindications: - pregnancy-category C - safety in lactation ? Dosage: 1) Intravenous: - Load 6 mg/kg IV over 20-30 minutes. - Drip 1 g in 250 mL D5W (4 mg/mL) at 0.5-0.7 mg/kg/hr (70 kg: 0.7 mg/kg/hr = 11 mL/hr). - Pediatrics: 1 mg/kg/hr. 2) Oral: 200 mg PO TID/QID. Tabs: 100 & 200 mg. Liquid: 125 mg/5 mL. Pharmacokinetics: - elimination: liver Adverse effects: (also see theophylline) 1) uncommon at serum concentrations < 20 ug/mL 2) not common (1-10%) - nausea/vomiting, restlessness, tachycardia 3) uncommon (< 1%) - skin rash, insomnia, irritability, tremor, seizures, gastric irritation, allergic reactions Drug interactions: (see theophylline)

Interactions

drug interactions

General

methylxanthine antiasthmatic agent pharmacologic combination

Database Correlations

PUBCHEM cid=9433

References

  1. The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill pg 619
  2. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Department of Veterans Affairs, VA National Formulary

Components

ethylenediamine theophylline (Slo-Phyllin, Elixophyllin, Uniphyl, Theo-24, Theo-Dur, Slo-bid, Theolair)