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aminopeptidase B; AP-B; arginine aminopeptidase; arginyl aminopeptidase (RNPEP, APB)
Function:
- exopeptidase which selectively removes Arg &/or Lys from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin & Arg(-1)-Lys(0)-somatostatin-14
- can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (putative)
- release of N-terminal Arg & Lys from oligopeptides when P1' is not Pro
- also acts on arylamides of Arg & Lys
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure: belongs to the peptidase M1 family
Compartment: secreted (putative)
Expression:
- expressed in liver & secreted
General
aminopeptidase
phosphoprotein
secreted protein
Properties
SIZE: entity length = 650 aa
MW = 73 kD
COMPARTMENT: extracellular compartment
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S7}
Substrate binding {298-302}
Zn+2-binding site
SITE: 325-325
glutamate residue {E326}
Zn+2-binding site
SITE: 329-329
Zn+2-binding site
SITE: 348-348
tyrosine residue {414}
Database Correlations
OMIM 602675
UniProt Q9H4A4
PFAM correlations
Entrez Gene 6051
Kegg hsa:6051
ENZYME 3.4.11.6
References
- UniProt :accession Q9H4A41
- Taylor A.
Aminopeptidases: structure and function.
FASEB J. 1993 Feb 1;7(2):290-8. Review.
PMID: 8440407