amiloride-sensitive cation channel 5; human intestine Na+ channell hINaC (ACCN5, ASIC5, HINAC)

Function: - cation channel that gives rise to very low constitutive currents in the absence of activation - the activated channel exhibits selectivity for Na⁺ - inhibited by amiloride Structure: - homotetramer or heterotetramer (putative) - belongs to the amiloride-sensitive Na⁺ channel family Compartment: cell membrane Expression: - detected in small intestine, duodenum & jejunum - detected at very low levels in testis & rectum

General

amiloride-sensitive cation channel glycoprotein

Properties

SIZE: entity length = 505 aa MW = 57 kD COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-61} transmembrane domain {62-82} exoplasmic loop {83-459} MOTIF: N-glycosylation site {N147} N-glycosylation site {N163} transmembrane domain {460-480} cytoplasmic domain {481-505}

Database Correlations

UniProt Q9NY37 Pfam PF00858 Entrez Gene 51802 Kegg hsa:5180

References

UniProt :accession Q9NY37