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amiloride-sensitive amine oxidase; histaminase; amiloride-binding protein 1; diamine oxidase; DAO; amiloride-binding protein; ABP; kidney amine oxidase (KAO, ABP1, AOC, DAO1)
Function:
- catalyzes degradation of compounds including: putrescine, histamine, spermine, & spermidine, substances involved in allergic & immune responses, cell proliferation, tissue differentiation, tumor formation, & possibly apoptosis
- placental DAO is thought to play a role in the regulation of female reproductive function
- topaquinone is generated by copper-dependent autoxidation of a specific Tyr
- inhibited by amiloride (competitive inhibition)
RCH(2)NH(2) + H2O + O2 RCHO + NH3 + H2O2
Cofactor:
- binds 1 copper ion per subunit (putative)
- binds 2 Ca+2 per subunit (putative)
- contains 1 topaquinone per subunit (putative)
Structure: belongs to the copper/topaquinone oxidase family
Compartment: secreted, extracellular space
Alternative splicing: named isoforms=2
Expression: placenta & kidney
Laboratory:
- diamine oxidase in serum/plasma
General
amine oxidoreductase
glycoprotein
Properties
SIZE: entity length = 751 aa
MW = 85 kD
MOTIF: signal sequence {1-19}
N-glycosylation site {N110}
N-glycosylation site {N168}
aspartate residue {D373}
tyrosine residue {Y461}
copper [Cu]-binding site
SITE: 510-510
MOTIF: histidine residue (3)
copper [Cu]-binding site
SITE: 512-512
MOTIF: histidine residue (3)
Ca+2-binding site
SITE: 519-519
Ca+2-binding site
SITE: 520-520
Ca+2-binding site
SITE: 521-521
N-glycosylation site {N538}
Ca+2-binding site
SITE: 562-562
binding site
SITE: 568-575
FOR-BINDING-OF: heparin
Ca+2-binding site
SITE: 653-653
Ca+2-binding site
SITE: 656-656
Ca+2-binding site
SITE: 658-658
Ca+2-binding site
SITE: 664-664
Ca+2-binding site
SITE: 665-665
copper [Cu]-binding site
SITE: 675-675
MOTIF: histidine residue (3)
N-glycosylation site {N745}
Database Correlations
OMIM 104610
UniProt P19801
PFAM correlations
Entrez Gene 26
KEGG correlations
ENZYME 1.4.3.6
References
UniProt :accession P19801