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Amelogenin, Y isoform (AMELY AMGL AMGY)
Function:
- role in biomineralization
- seems to regulate formation of crystallites during the secretory stage of tooth enamel development
- role in the structural organization & mineralization of developing enamel (putative)
- amelogenin is the predominant protein in developing dental enamel
Structure: belongs to the amelogenin family
Compartment:
- secreted, extracellular space, extracellular matrix
Alternative splicing: named isoforms=2
Expression:
- transiently but abundantly expressed by ameloblasts during tooth development.
Genetics: this isoform is encoded on the Y chromosome
General
amelogenin
Properties
SIZE: entity length = 206 aa
MW = 23 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-16}
Ser phosphorylation site {S32}
glutamine-rich region {86-170}
MOTIF: glutamine residue (SEVERAL)
Database Correlations
OMIM 410000
UniProt Q99218
Pfam PF02948
Entrez Gene 266
Kegg hsa:266
References
- OMIM :accession 410000
- Entrez Gene :accession 266
- UniProt :accession Q99218