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ALS2 C-terminal-like protein (ALS2CL)
Function:
- acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase
- regulates the ALS2-mediated endosome dynamics
- forms a heteromeric complex with ALS2
- interacts with ALS2 & RAB5A
Structure:
- homodimer
- contains 8 MORN repeats
- contains 1 VPS9 domain
Compartment:
- cytoplasm
- distributed onto vesicular compartments in the cytoplasm with strong punctated staining
- colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of cells
Alternative splicing: named isoforms=5
Expression: expressed in heart & kidney
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: entity length = 953 aa
MW = 108 kD
COMPARTMENT: cytoplasm
MOTIF: MORN repeat {358-380}
MORN repeat {381-403}
MORN repeat {409-431}
MORN repeat {432-452}
MORN repeat {459-479}
MORN repeat {483-505}
MORN repeat {506-528}
MORN repeat {529-552}
VPS9 {796-942}
Database Correlations
UniProt Q60I27
PFAM correlations
References
UniProt :accession Q60I27