alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (galNAc alpha-2,6-sialyltransferase VI, ST6galNAc VI, hST6galNAc VI, sialyltransferase 7F, ST6GALNAC6, SIAT7F, UNQ708/PRO1359)

Function: - alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides - activity toward GD1a, GT1b & GM1b - no activity toward glycoproteins - responsible for biosynthesis of disialylgalactosylgloboside (DSGG) from monosialylgalactosylgloboside (MSGG) in normal & malignant kidney Kinetic parameters: - KM=0.33 mM for GM1b - KM=0.46 mM for sialyl-Lc4 Structure: belongs to the glycosyltransferase 29 family Compartment: - Golgi membrane Alternative splicing: named isoforms=2 Expression: - expressed in kidney, in proximal tubule epithelial cells Pathology: - expressed in colon cell lines - down-regulated in renal cancers - participates in the synthesis of disialyl Lewis a (Le(a)), a representative tumor-associated antigen in cancers of the pancreas & colon, in colon tissues

General

glycoprotein membrane protein sialyltransferase

Properties

SIZE: entity length = 333 aa MW = 38 kD COMPARTMENT: golgi MOTIF: arginine-rich region {30-33} MOTIF: arginine residue (SEVERAL) transmembrane domain {44-64} N-glycosylation site {N98} cysteine residue {C108} MODIFICATION: cysteine residue {C256} serine-rich region {112-115} MOTIF: serine residue (SEVERAL) cysteine residue {C256} MODIFICATION: cysteine residue {C108}

Database Correlations

UniProt Q969X2 Pfam PF00777 Kegg hsa:3081 ENZYME 2.4.99.1

References

UniProt :accession Q969X2