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alpha-mannosidase 2x; alpha-mannosidase IIx; man IIx; mannosidase alpha class 2A member 2; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (MAN2A2, MANA2X)
Function:
1) protein modification; protein glycosylation
2) catalyzes the 1st committed step in the biosynthesis of complex N-glycans (N-glycosylation)
3) controls conversion of high mannose to complex N-glycans
4) final hydrolytic step in the N-glycan maturation
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure:
- homodimer, disulfide-linked
- belongs to the glycosyl hydrolase 38 family
Compartment:
- Golgi membrane
- single-pass type 2 membrane protein (putative)
Alternative splicing:
- named isoforms=2
- at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Related
Asn glycosylation
General
glycoprotein
glycosidase (glycoside hydrolase)
membrane protein
Properties
SIZE: entity length = 1150 aa
MW = 131 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {6-26}
N-glycosylation site {N95}
Zn+2-binding site
SITE: 175-175
Zn+2-binding site
SITE: 177-177
aspartate residue {D289}
Zn+2-binding site
SITE: 289-289
N-glycosylation site {N305}
Zn+2-binding site
SITE: 569-569
N-glycosylation site {N1093}
N-glycosylation site {N1131}
Database Correlations
OMIM 600988
UniProt P49641
PFAM correlations
Entrez Gene 4122
Kegg hsa:4122
ENZYME 3.2.1.114
References
UniProt :accession P49641