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alpha mannosidase-2; ER/GOLGI alpha-mannosidase (MAN2A1, MANA2)
Function:
- catalyzes 1st committed step in the biosynthesis of complex N-glycans
- controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway
- protein modification; protein glycosylation
- hydrolysis of the terminal (1->3)- & (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide man(5)(GlcNAc)(3)
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure:
- homodimer, disulfide-linked (putative)
- glycosylated (putative)
- belongs to the glycosyl hydrolase 38 family
Compartment:
- Golgi membrane
General
alpha-mannosidase (MANA)
glycoprotein
membrane protein
phosphoprotein
Properties
SIZE: entity length = 1144 aa
MW = 131 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {6-26}
N-glycosylation site {N78}
Ser phosphorylation site {S80}
Ser phosphorylation site {S82}
N-glycosylation site {N93}
Zn+2-binding site
SITE: 175-175
Zn+2-binding site
SITE: 177-177
aspartate residue {D289}
Zn+2-binding site
SITE: 289-289
Zn+2-binding site
SITE: 569-569
N-glycosylation site {N1125}
Database Correlations
OMIM 154582
UniProt Q16706
PFAM correlations
Entrez Gene 4124
Kegg hsa:4124
ENZYME 3.2.1.114
References
UniProt :accession Q16706