alpha-lactalbumin; lactose synthase B protein; lysozyme-like protein 7 (LALBA LYZL7)

Function: - regulatory subunit of lactose synthase (LS) - changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme; this enables LS to synthesize lactose, the major carbohydrate component of milk - in other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins Structure: belongs to the glycosyl hydrolase 22 family Compartment: secreted Expression: - mammary gland specific - secreted in milk

General

Ca+2 binding protein glycoprotein milk protein protein subunit

Properties

SIZE: entity length = 142 aa MW = 16 kD MOTIF: signal sequence {1-19} cysteine residue {C25} MODIFICATION: cysteine residue {C139} cysteine residue {C47} MODIFICATION: cysteine residue {C130} N-glycosylation site {N64} cysteine residue {C80} MODIFICATION: cysteine residue {C96} N-glycosylation site {N90} cysteine residue {C92} MODIFICATION: cysteine residue {C110} cysteine residue {C96} MODIFICATION: cysteine residue {C80} Ca+2-binding site SITE: 97-108 cysteine residue {C110} MODIFICATION: cysteine residue {C92} cysteine residue {C130} MODIFICATION: cysteine residue {C47} cysteine residue {C139} MODIFICATION: cysteine residue {C25}

Database Correlations

OMIM 149750 UniProt P00709 Pfam PF00062 Entrez Gene 3906 Kegg hsa:3906

References

UniProt :accession P00709