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mitochondrial 2-oxoglutarate/malate carrier protein; OGCP; solute carrier family 25 member 11 (SLC25A11 SLC20A4)
Function:
- catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids
- plays a role in several metabolic processes, including:
a) malate-aspartate shuttle
b) oxoglutarate/isocitrate shuttle
c) gluconeogenesis from lactate
d) nitrogen metabolism
Structure:
- belongs to the mitochondrial carrier family
- contains 3 solcar repeats
Compartment: mitochondrial inner membrane
General
mitochondrial membrane protein
regulatory molecule
solute carrier family 25 (SLC25, SLC25A)
Properties
SIZE: entity length = 314 aa
MW = 34 kD
COMPARTMENT: mitochondria
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Solcar {23-108}
MOTIF: transmembrane domain {24-42}
transmembrane domain {83-101}
Tyr phosphorylation site {Y102}
Solcar {117-208}
MOTIF: transmembrane domain {119-140}
transmembrane domain {183-202}
Tyr phosphorylation site {Y202}
Solcar {217-306}
MOTIF: transmembrane domain {222-240}
transmembrane domain {281-300}
Database Correlations
OMIM 604165
UniProt Q02978
Pfam PF00153
Kegg hsa:8402
References
- UniProt :accession Q02978
- Textbook of Biochemistry with Clinical Correlations,
3rd ed., TM Devlin (ed), Wiley-Liss, NY 1992 pg 266