alpha-globin transcription factor CP2 (transcription factor LSF, SAA3 enhancer factor, TFCP2, LSF, SEF)

Function: 1) binds a variety of cellular & viral promoters including: - fibrinogen, alpha-globin, SV40 & HIV-1 promoters 2) activation of the alpha-globin promoter in erythroid cells occurs via synergistic interaction with UBP1 3) component of stage selector protein complex (SSP complex) 4) facilitates interaction of the gamma-globin genes with enhancer elements in the locus control region in fetal erythroid cells 5) binds to stage selector element (SSE) in proximal gamma-globin promoter 6) binds to DNA as a dimer - isoform 2 does not bind to DNA or affect the binding of isoform 1 to DNA 7) interacts with UBP1 & PIAS1 8) component of a complex containing TFCP2, UBP1 & PIAS1 Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - ubiquitous - expressed in fetal erythroid tissue

Properties

SIZE: MW = 57 kD entity length = 502 aa COMPARTMENT: cell nucleus MOTIF: binding site SITE: 133-395 FOR-BINDING-OF: deoxyribonucleic acid (DNA) MOTIF: proline-rich region SITE: 314-319 MOTIF: proline residue (SEVERAL) glutamine-rich region {396-413} MOTIF: glutamine residue (SEVERAL)

Database Correlations

OMIM 189889 UniProt Q12800 Pfam PF04516

References

UniProt :accession Q12800