alpha-fetoprotein enhancer-binding protein; AT motif-binding factor 1 (ATBF1, ZFHX3)

Function: 1) transcriptional activator 2) binds to AT-rich core sequence of the enhancer element of AFP gene 3) interacts with FNBP3 Compartment: nucleus Alternative splicing: named isoforms=2

General

C2H2 type zinc finger protein transcription factor (TF)

Properties

SIZE: MW = 404 kD entity length = 3703 aa COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 104-107 MOTIF: proline residue (SEVERAL) Zn finger C2H2-type SITE: 282-305 EFFECTOR-BOUND: Zn+2 glutamate-rich region {460-489} MOTIF: glutamate residue (SEVERAL) Zn finger C2H2-type (3) SITE: 640-750 EFFECTOR-BOUND: Zn+2 alanine-rich region {770-784} MOTIF: alanine residue (SEVERAL) Zn finger C2H2-type (12) SITE: 804-1620 EFFECTOR-BOUND: Zn+2 glutamine-rich region {1723-1857} (3) MOTIF: glutamine residue (SEVERAL) Zn finger C2H2-type SITE: 1983-2006 EFFECTOR-BOUND: Zn+2 proline-rich region SITE: 2037-2052 MOTIF: proline residue (SEVERAL) homeodomain (2) SITE: 2145-2301 Zn finger C2H2-type (2) SITE: 2328-2552 EFFECTOR-BOUND: Zn+2 homeodomain SITE: 2641-2700 Zn finger C2H2-type SITE: 2711-2734 EFFECTOR-BOUND: Zn+2 homeodomain SITE: 2944-3003 Zn finger C2H2-type SITE: 3024-3048 EFFECTOR-BOUND: Zn+2 glutamine-rich region {3197-3209} MOTIF: glutamine residue (SEVERAL) proline-rich region SITE: 3210-3214 MOTIF: proline residue (SEVERAL) glutamine-rich region {3227-3395} (3) MOTIF: glutamine residue (SEVERAL) glycine-rich region {3507-3527} Zn finger C2H2-type SITE: 3529-3553 EFFECTOR-BOUND: Zn+2 proline-rich region SITE: 3597-3600 MOTIF: proline residue (SEVERAL) serine-rich region {3636-3639} MOTIF: serine residue (SEVERAL)

Database Correlations

OMIM 104155 UniProt Q15911 PFAM correlations

References

UniProt :accession Q15911