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alpha amanitin

Epidemiology: - alpha-Amanitin is derived from the poisonous mushroom Amanita phalloides (death cup, destroying angel) Pathology: - it inhibits RNA polymerase-2 by binding very tightly to the enzyme (K=10-8M) - the mushroom also contains phalloidin, an inhibitor of cytoskeletal function - alpha-Amanitin is 10-20 times more toxic than phalloidin Laboratory: - alpha-amantin in urine - alpha-amantin + gamma-amantin in urine

General

amanitin

Properties

INHIBITS: RNA polymerase-2

References

  1. Merck Index. Merck & Co. Inc., 12th ed.
  2. Stryer Biochemistry WH Freeman & Co, New York, 1988 pg 717