alpha-2C adrenergic receptor; alpha-2C adrenoreceptor; alpha-2C adrenoceptor; alpha-2 adrenergic receptor subtype C4 (ADRA2C, ADRA2L2, ADRA2RL2)

Function: alpha-2 adrenergic receptor Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Polymorphism: - the del322-325 variant has a significant loss of function; it is approximately 10 times more frequent in African- Americans compared with Caucasians (allele frequencies 0.381 versus 0.040)

General

alpha-2 adrenergic receptor glycoprotein

Properties

SIZE: entity length = 462 aa MW = 50 kD COMPARTMENT: synaptic membrane CELL: neuron MOTIF: exoplasmic domain {1-51} MOTIF: N-glycosylation site {N19} N-glycosylation site {N33} transmembrane domain {52-76} cytoplasmic loop {77-88} transmembrane domain {89-114} exoplasmic loop {115-124} MOTIF: cysteine residue {C124} MODIFICATION: cysteine residue {C202} transmembrane domain {125-147} MOTIF: aspartate residue {131} cytoplasmic loop {148-168} transmembrane domain {169-191} exoplasmic loop {192-207} MOTIF: cysteine residue {C202} MODIFICATION: cysteine residue {C124} transmembrane domain {208-231} MOTIF: serine residue {214} serine residue {218} cytoplasmic loop {232-379} MOTIF: arginine-rich region {294-308} MOTIF: arginine residue (SEVERAL) transmembrane domain {380-407} exoplasmic loop {408-420} transmembrane domain {421-441} cytoplasmic domain {442-462}

Database Correlations

OMIM 104250 UniProt P18825 Pfam PF00001 Entrez Gene 152 Kegg hsa:152

References

UniProt :accession P18825