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alpha-2A adrenergic receptor; alpha-2A adrenoreceptor; alpha-2A adrenoceptor; alpha-2AAR; alpha-2 adrenergic receptor subtype C10 (ADRA2A, ADRA2R, ADRAR)
Function:
- alpha-2 adrenergic receptor
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
General
alpha-2 adrenergic receptor
glycoprotein
Properties
SIZE: entity length = 450 aa
MW = 49 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-33}
MOTIF: N-glycosylation site {N10}
N-glycosylation site {N14}
transmembrane domain {34-59}
cytoplasmic loop {60-70}
transmembrane domain {71-96}
exoplasmic loop {97-106}
MOTIF: cysteine residue {C106}
MODIFICATION: cysteine residue {C188}
transmembrane domain {107-129}
MOTIF: aspartate residue {113}
cytoplasmic loop {130-149}
transmembrane domain {150-173}
exoplasmic loop {174-192}
MOTIF: cysteine residue {C188}
MODIFICATION: cysteine residue {C106}
transmembrane domain {193-217}
MOTIF: serine residue {200}
serine residue {204}
cytoplasmic loop {218-374}
MOTIF: Ser phosphorylation site {S297}
Ser phosphorylation site {S298}
Ser phosphorylation site {S299}
transmembrane domain {375-399}
exoplasmic loop {400-406}
transmembrane domain {407-430}
cytoplasmic domain {431-450}
MOTIF: cysteine residue {C442}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 104210
UniProt P08913
Pfam PF00001
Entrez Gene 150
Kegg hsa:150
References
- UniProt :accession P08913
- SeattleSNPs
http://pga.gs.washington.edu/data/adra2a/
- Lomasney JW, Lorenz W, Allen LF, King K, Regan JW,
Yang-Feng TL, Caron MG, Lefkowitz RJ.
Expansion of the alpha 2-adrenergic receptor family: cloning
and characterization of a human alpha 2-adrenergic receptor
subtype, the gene for which is located on chromosome 2.
Proc Natl Acad Sci U S A. 1990 Jul;87(13):5094-8.
PMID: 2164221