alpha-1-antitrypsin-related protein; Serpin A2 (SERPINA2, SERPINA2P, ARGS, ATR, PIL)

Function: - could be a serine protease inhibitor Structure: - the reactive center loop (RCL) extends out from the body of the protein & directs binding to the target protease - the protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site & the Ser hydroxyl of the protease - the resulting inactive serpin-protease complex is highly stable - belongs to the serpin family Note: could be the product of a pseudogene

General

alpha 1 globulin glycoprotein serine protease inhibitor; serpin

Properties

SIZE: entity length = 420 aa MW = 48 kD COMPARTMENT: plasma MOTIF: signal sequence {1-21} N-glycosylation site {N56} N-glycosylation site {N109} N-glycosylation site {N147} N-glycosylation site {N273} peptide motif {384-385} INHIBITS: serine protease

Database Correlations

OMIM 107410 UniProt P20848 Pfam PF00079

References

UniProt :accession P20848