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alpha-1,4-N-acetylglucosaminyltransferase (Alpha4GnT, A4GNT)
Function:
1) glycosylation
2) necessary for the synthesis of mucin type 3
3) catalyzes transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans
Structure:
- belongs to the alpha 1,4-glycosyltransferase family
- conserved DXD motif is involved in enzyme activity
Compartment: Golgi membrane
Expression: detected in stomach & pancreas
General
glycoprotein
glycosyltransferase
membrane protein
Properties
SIZE: MW = 39 kD
entity length = 340 aa
COMPARTMENT: golgi
MOTIF: transmembrane domain {5-25}
N-glycosylation site {N99}
N-glycosylation site {N138}
DXD motif {167-169}
N-glycosylation site {N251}
N-glycosylation site {N282}
Database Correlations
UniProt Q9UNA3
PFAM correlations
Entrez Gene 51146
Kegg hsa:51146
References
- UniProt :accession Q9UNA3
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/
- Functional glycomics gateway - GTase
alpha-1,4-N-acetylglucosaminyltransferase
http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewglycoEnzyme.jsp?gbpId=gt_hum_532