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alpha-1A adrenergic receptor; alpha 1A-adrenoreceptor; alpha 1A-adrenoceptor; alpha-1C adrenergic receptor; alpha-adrenergic receptor 1c (ADRA1A, ADRA1C)
Function:
- alpha-adrenergic receptor
- mediates its action by association with G proteins that activate a phosphatidylinositol- Ca+2 second messenger system
- effect mediated by G(q) & G(11) proteins
- carboxyl-terminal Ser or Thr residues may be phosphorylated
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Alternative splicing: named isoforms=9
Expression:
- expressed in heart, brain, liver & prostate
- not expressed in kidney, lung, adrenal, aorta & pituitary
- isoform 4 is the most abundant isoform expressed in prostate; high levels also detected in liver & heart
General
alpha-1 adrenergic receptor
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 466 aa
MW = 51 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-27}
MOTIF: N-glycosylation site {N7}
N-glycosylation site {N13}
N-glycosylation site {N22}
transmembrane domain {28-51}
cytoplasmic loop {52-64}
transmembrane domain {65-88}
exoplasmic loop {89-99}
MOTIF: cysteine residue {C99}
MODIFICATION: cysteine residue {C176}
transmembrane domain {100-122}
cytoplasmic loop {123-143}
transmembrane domain {144-167}
exoplasmic loop {168-181}
MOTIF: cysteine residue {C176}
MODIFICATION: cysteine residue {C99}
transmembrane domain {182-205}
cytoplasmic loop {206-273}
MOTIF: Ser phosphorylation site {S215}
transmembrane domain {274-297}
exoplasmic loop {298-305}
transmembrane domain {306-329}
cytoplasmic domain {330-466}
MOTIF: cysteine residue {C345}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 104221
UniProt P35348
Pfam PF00001
Entrez Gene 148
Kegg hsa:148
References
UniProt :accession P35348