all-trans-retinol 13,14-reductase; all-trans-13,14-dihydroretinol saturase; RetSat; PPAR-alpha-regulated & starvation-induced gene protein (RETSAT, PPSIG, UNQ439/PRO872)

Function: 1) retinol saturase, metabolism of vitamin A 2) saturation of the 13-14 double bond of all-trans-retinol to produce all-trans-13,14-dihydroretinol 3) activity toward all-trans-retinol as substrate 4) does NOT use all-trans-retinoic acid nor 9-cis-retinol, 11-cis-retinol or 13-cis-retinol isomers as substrates Cofactor: NAD, NADP, or FAD Structure: - belongs to the carotenoid/retinoid oxidoreductase family, CrtISO subfamily Compartment: endoplasmic reticulum membrane, peripheral membrane Alternative splicing: named isoforms=2

General

flavoprotein membrane protein oxidoreductase

Properties

SIZE: MW = 67 kD entity length = 610 aa COMPARTMENT: endoplasmic reticulum MOTIF: signal sequence {1-18} cofactor-binding site [70-98] COFACTOR-BOUND: flavin adenine dinucleotide

Database Correlations

UniProt Q6NUM9 Entrez Gene 54884 Kegg hsa:54884 ENZYME 1.3.99.23

References

UniProt :accession Q6NUM9