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allopurinol/lesinurad (Duzallo)
Indications: gout (FDA-approved August 2017)
Dosage:
- once daily oral dosing
- in the morning with food & water
- stay well hydrated
- drink about 2 L of liquid a day when taking the drug
Tabs:
- lesinurad 200 mg plus allopurinol 300 mg
- lesinurad 200 mg plus allopurinol 200 mg
Adverse effects:
- headache
- influenza
- GERD
- increased serum creatinine (generally transient) [2]
Boxed warning: risk for acute renal failure
Mechanism of action:
- may diminish serum uric acid more than allopurinol alone
- no difference in gout flares or tophi [2]
Interactions
drug interactions
General
pharmacologic combination
References
- Brooks M
FDA Clears First Fixed-Dose Combination Treatment for Gout.
Medscape - Aug 21, 2017.
http://www.medscape.com/viewarticle/884534
- Saag KG, Fitz-Patrick D, Kopicko J et al.
Lesinurad combined with allopurinol: A randomized, double-blind,
placebo-controlled study in gout patients with an inadequate
response to standard-of-care allopurinol (a US-based study).
Arthritis Rheumatol 2017 Jan; 69:203.
PMID: 27564409 Free Article
https://onlinelibrary.wiley.com/doi/abs/10.1002/art.39840
- Bardin T, Keenan RT, Khanna PP et al.
Lesinurad in combination with allopurinol: A randomised,
double-blind, placebo-controlled study in patients with gout
with inadequate response to standard of care (the multinational
CLEAR 2 study).
Ann Rheum Dis 2017 May; 76:811
PMID: 27821644 Free PMC Article
https://ard.bmj.com/content/76/5/811
Components
allopurinol (Zyloprim, Lopurin, Zurinol)
lesinurad (Zurampic)