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alkaline phytoceramidase; aPHC; alkaline ceramidase; alkaline dihydroceramidase SB89 (PHCA, APHC, ACER3)
Function:
- hydrolyzes only phytoceramide into phytosphingosine & free fatty acid
- does not have reverse activity
- activated by Ca+2 & inhibited by Zn+2
Structure: belongs to the alkaline ceramidase family
Compartment:
- endoplasmic reticulum membrane
- Golgi membrane
Expression:
- ubiquitously expressed
- highest expression in placenta
General
ceramidase
glycoprotein
transmembrane 7 protein
Properties
SIZE: MW = 32 kD
entity length = 267 aa
COMPARTMENT: golgi
endoplasmic reticulum
MOTIF: N-glycosylation site {N24}
transmembrane domain {29-51}
transmembrane domain {63-84}
transmembrane domain {94-111}
transmembrane domain {118-137}
transmembrane domain {147-169}
transmembrane domain {174-196}
transmembrane domain {216-238}
Database Correlations
UniProt Q9NUN7
Pfam PF05875
References
UniProt :accession Q9NUN7