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alkaline ceramidase 1 (alkaline CDase-1, AlkCDase 1, acylsphingosine deacylase 3, N-acylsphingosine amidohydrolase 3, ASAH3, ACER1)
Function:
- hydrolyzes the sphingolipid ceramide into sphingosine & free fatty acid at an optimal pH of 8.0
- highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone
- may have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids
N-acylsphingosine + H2O a carboxylate + sphingosine
Inhibition:
- inhibited by sphingosine
Structure: belongs to the alkaline ceramidase family
Compartment: endoplasmic reticulum membrane
Expression: Mainly expressed in epidermis
General
ceramidase
glycoprotein
transmembrane 7 protein
Properties
SIZE: MW = 31 kD
entity length = 264 aa
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {28-48}
transmembrane domain {58-78}
transmembrane domain {82-102}
N-glycosylation site {N116}
transmembrane domain {120-137}
transmembrane domain {139-159}
transmembrane domain {177-197}
transmembrane domain {207-227}
Database Correlations
UniProt Q8TDN7
Pfam PF05875
ENZYME 3.5.1.23
References
UniProt :accession Q8TDN7